Like tnt, it was found to be toxic to the munition workers handling it. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. This material does not contain any class 1 ozone depletors. Anyway, i learned about a chemical called 2, 4 dinitrophenol or dnp, which is what they call it in bodybuilding circles. Tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Dinitrophenol is an ionophoric compound that short circuits mitochondrial atp production. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2, 4 dinitrophenol 2, 4 dnp. All structured data from the file and property namespaces is available under the creative commons cc0 license. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b. The mechanism of uncoupling of oxidative phosphorylation by 2.
New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. Jan 10, 2004 there has been a resurgence in the use of 2, 4 dinitrophenol, c6h4n2o5 recently as an illegal weight loss drug. For additional information on the health effects of this chemical, interested parties are referred to the. Strictly speaking, the former is more correct, though the latter is commonly used to refer to it too. Analytical, diagnostic and therapeutic context of 2,4. Dinitrophenol definition of dinitrophenol by medical dictionary. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Any one of six isomeric substituent products of benzene having the empirical formula 2c6h3oh explanation of 2,4dinitrophenol. A phenolate anion obtained from 2, 4 dinitrophenol. Chronic oral exposure to 2, 4 dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, cns, and cardiovascular system. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. Chemical compound and disease context of 2,4dinitrophenol.
Uses the predominant use of 2, 4 dinitrotoluene is as an intermediate in the manufacture of polyurethanes. The primary hazard is from blast of an instantaneous explosion and not flying projectiles and fragments. Jan 10, 2004 death within 44 days of 2, 4 dinitrophenol intake we report the case of a 50yearold obese man 115 kg body mass at 1. Sports medicinebodybuilding a potent nonselective inhibitor of oxidative phosphorylation, which results in increased metabolism and increased body temperature, and has been used illegally for weight control toxicology any of a family of compounds used in weed control and, at one time, for weight control, which may cause death.
She was managed with aggressive, invasive cooling measures and 2. For your desktop, server, in your web browser and as developer libraries. We present a case of a healthy 25yearold girl who took two tablets of dnp, purchased from an overseas online retailer. Epa rfdrfc work group and determined to be inadequate for the derivation of an inhalation rfc. A wide variety of dnp 2 4 dinitrophenol options are available to you. Using 2, 4 dnp as a shell filling was less sensitive than picric acid on its own. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point. How to sew a reusable face mask with filter pocket diy fabric face mask batch sew medical mask duration. Buy dnp 2,4dinitrophenol not for human consumption. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this story. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Other applications include uses as an intermediate in dye processes and in smokeless gunpowders. There is no compound on earth that can burn fat at the rate of dnp. Dnp ist ein gelber kristalliner feststoff mit phenolartigem geruch.
It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. After 43 days of taking dnp, the man showed signs of intoxication with nausea, vomiting, and attacks of sweating. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this. Files are available under licenses specified on their description page. Associations of 2,4dinitrophenol with other chemical compounds. The chemical structure of 2,4dinitrophenol is shown in figure 1. Download osgeo4w installer 32 bit or 64 bit and start it. This material does not contain any class 2 ozone depletors. Uses the predominant use of 2,4dinitrotoluene is as an intermediate in the manufacture of polyurethanes. For the sake of clarity, ill use 2,4dnph throughout here. Incompatible with heavy metals and their compounds.
Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. The mechanism of uncoupling of oxidative phosphorylation. Death within 44 days of 2,4dinitrophenol intake we report the case of a 50yearold obese man 115 kg body mass at 1. Imagine a global collaborative knowledge base for original thoughts nature genetics. A year or more ago, i was on an antidepressant regimen that made me gain a lot of weight. It has a role as a bacterial xenobiotic metabolite. Structure, properties, spectra, suppliers and links for. Later on in the 19 th century chemists invented tnt 2, 4,6trinitrotoluene and 2, 4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings. These features are all too frequently fatal in spite of intensive medical treatment. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and. Pdf two deaths attributed to the use of 2,4dinitrophenol. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions.
It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. Dinitrophenol is an ionophoric compound that short circuits mitochondrial atp. There has been a resurgence in the use of 2,4dinitrophenol, c6h4n2o5 recently as an illegal weight loss drug. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. This page was last edited on 12 february 2016, at 20. Warnings issued over deadly dnp diet drug thursday 19 september 20 tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Dnp 2,4dinitrophenol dnp was first introduced to the bodybuilding world by dan duchaine. Also incompatible with strong oxidizing agents, strong bases and reducing agents. Binary packages installers are available from this page. Selective adsorption and efficient photodegradation of 2, 4 dinitrophenol in aqueous solution, journal of hazardous materials, vol. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole.
Youve probably seen 2,4dinitrophenylhydrazine referred to alternately as 2,4dnph or 2,4dnp. Sep 17, 2015 buy dnp 2, 4 dinitrophenol not for human consumption. When in a dry form, it is a high explosive and has an instantaneous explosion hazard. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2,4dinitrophenol 2,4dnp. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2,4dinitrophenol.
Dnp is used in developing photography, killing fungi, and as an industrial pesticide. Dinitrophenol definition of dinitrophenol by medical. Summary of 2,4dinitrophenol primary information, health benefits, side effects, usage, and other important details. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and i was on an ankle monitor and stuck at home at the time, which made it pretty hard for me to get any exercise. Later on in the 19 th century chemists invented tnt 2,4,6trinitrotoluene and 2,4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings.
Summary of 2, 4 dinitrophenol primary information, health benefits, side effects, usage, and other important details dinitrophenol is an ionophoric compound that short circuits mitochondrial atp production. Web based editing in qgis cloud lutra consulting working with qgis 3d part 2. Using 2,4dnp as a shell filling was less sensitive than picric acid on its own. What is 2,4dnph and why are schools carrying out controlled. Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Due credit and reputation for authors authorship tracking technology.
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